Magnanti went on to work as a biostatistician in the Newcastle University Paediatric and Lifecourse Epidemiology Research Group (PLERG), researching a possible link between the occurrence of thyroid cancer in under-25s in NE England and radioiodine fallout exposure from Chernobyl in Ukraine. The paper concludes that while the sustained rise in thyroid carcinoma in Cumbria could be consistent with the fallout patterns, the rising trends in Durham and Northumberland cannot be attributed to this exposure, and there may be other factors influencing the increase.

After her pseudonymous publishing career Magnanti was identified to be working as a research associate in developmental neurotoxicology and cancer epidemiology at the Bristol Initiative for Research of Child Health (BIRCH), part of Bristol University's Centre for Nanoscience and Quantum Information. Specifically she was part of the EU-funded Henvinet consortium, researching the policies for assessing the risks of developmental neuropathology from exposure to organophosphates. She collaborated on several EU project policy documents regarding human developmental risks of environmental exposure to chlorpyrifos, pthalates, and DecaBDE and HBCD.

In 2011 Brooke Magnanti published a statistical re-analysis criticising the Lilith Report on Lap Dancing and Striptease in the Borough of Camden, a study which had found that sexual crimes have increased after the opening of four lap dancing venues in the area. Magnanti concluded in her paper that the study had significant methodological errors. Furthermore, according to Magnanti's paper, in the decade since lap dancing became legal Camden has seen fewer recorded rapes than other comparable boroughs of London, even those with fewer strip clubs or none. Summaries of the findings were printed in several regional and national papers such as the Guardian and the Camden New Journal.

In early 2012, Magnanti published a nonfiction popular science book under her real name entitled The Sex Myth. It covered topics in sexuality studies and sociological research in the effects of adult entertainment and sex work.

Reviewing for The Observer Catherine Hakim wrote "Magnanti offers a pretty sharp analysis of sexual politics: who fabricates the myths and why, the role of both rightwing and leftwing media in building up moral panics, the vast sums obtained by the pressure groups that profit from them, and, more recently, too, by the pharmaceutical companies that plan to profit from newly invented sexual diseases."

It drew less favourable reviews from radical feminists such as Julie Bindel, whose writing was extensively criticised in the book and who stated "I disagree with just about everything she has to say".

A television series loosely based on the first book was in development with Channel 4 in the UK, but eventually aired on ITV2 as Secret Diary of a Call Girl. The first series aired from 27 September 2007 to 15 November 2007 starring Billie Piper as Hannah Baxter (Belle). It is now being shown in the US on Showtime. Magnanti met Piper in the course of preparing for the role but maintained her pseudonymity. A half-hour TV programme covering a meeting and conversation between the two was broadcast on ITV2 on 25 January 2010. The second series commenced broadcasting in the UK on ITV2 on 11 September 2008.

The third series began broadcasting in the UK and North America in January 2010. The fourth and final series started broadcasting in the UK on ITV2 in February 2011.

Magnanti is married and lives in Lochaber in the Scottish highlands.

In June 2011, an ex-boyfriend issued a libel writ against The Sunday Times for a claim of defamation caused by his mention in the paper. The writ, filed by Flight Lieutenant Owen Morris of RAF Lossiemouth, claimed that following her outing, he was identified as her former boyfriend and therefore mentions of his harassment in the articles had been damaging even though they did not mention him by name. The Sunday Times printed an apology in February 2012, followed by The Week who agreed to pay damages.